Collecting Runes and crafting Runewords are some of the most fascinating parts of the loot system in D2R Ladder Items. With methods of every class, mercenary, and level range, Runewords aren't just fun to produce, but they're vital. As soon as you start finding runes, it is best to look to generate some of such Runewords.

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Rather compared to the most powerful Runewords, the entries below include the most valuable options. These items vary in rarity and might be good for early, mid, or late-game. Although Last Wish and Phoenix are excellent Runewords, their rarity outweighs their usefulness in this list.

Physical damage dealers across the Nightmare Difficulty could well be wise to generate to a Duress. This 3-socket Runeword offers you Faster Hit Recovery, Enhanced Damage, and Cold Damage. In addition to that, you receive Crushing Blow, Open Wounds, massive Defense, and All Res.

Amazons and Barbarians are particularly strong having a Duress and mercs beyond Act 3 are able to use it as a hand-me-down. Duress may be known as a mid-to-low-tier Runeword, using Shael, Um, & Thul. The Shael and Thul it is best to be able to find easily enough, the Um must come from your Hell Hellforge or through pure luck.

Rhyme is surely an early game Runeword that can be useful for a crucial part of the game. In a 2-open-socket shield, adding a Shael & Eth will grant you strong benefits. Some of the highlights include +25 to All Resistances, Regenerate Mana 15%, 25% Magic Find, and Cannot Be Frozen.

While the opposite stats are welcomed and produce the item stronger, the resistances and thawing are certainly powerful. Rhyme is worthy of making the way it requires low runes which enable it to be equipped over a Level 29 character.

As you progress into Nightmare and Hell, your Resistances help keep taking hits. While you’re leveling up and searching for better gear, Smoke is really a convenient approach to keep your Resistances high. With +50 to All Res and 20% Faster Hit Recovery, Smoke are able to keep you sturdy before the late game.

If you’re having resistance issues heading into the final stages of the game, a Smoke could really help out. If it only had +1 or 2 to Skills, this will be one with the best armors hanging around.

With +1 Skills, +10 Energy, and +2 Mana After Kill, Lore is fantastic on casters. Sorceresses, Elemental Druids, and Hammerdins are probably the classes who make one the moment they can. Lore also comes with Lightning Res, and Damage Reduction, as well as a very accessible Level 27 requirement.

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Runewords are extremely rarely strong on all characters, but Lore will be the exception that defies the standard. While Lore is particularly good on casters, it could possibly still be greater than any other helm you’ll locate in the early game.